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Article

Individual bacteria in structured environments rely on phenotypic resistance to phage.

PLoS biology - 1 Oct 2021

Attrill Erin L, Claydon Rory, Łapińska Urszula, Recker Mario, Meaden Sean, Brown Aidan T, Westra Edze R, Harding Sarah V, Pagliara Stefano

Abstract excerpt

Bacteriophages represent an avenue to overcome the current antibiotic resistance crisis, but evolution of genetic resistance to phages remains a concern. In vitro, bacteria evolve genetic resistance, preventing phage adsorption or degrading phage DNA. In natural environments, evolved resistance is lower possibly because the spatial heterogeneity within biofilms, microcolonies, or wall populations favours...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 34637438
DOI: 10.1371/journal.pbio.3001406
PMCID: PMC8509860

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