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Article

Heterozygosity of the major histocompatibility complex predicts later self-reported pubertal maturation in men.

Scientific reports - 6 Oct 2021

Arnocky Steven, Hodges-Simeon Carolyn, Davis Adam C, Desmarais Riley, Greenshields Anna, Liwski Robert, Quillen Ellen E, Cardenas Rodrigo, Breedlove S Marc, Puts David

Abstract excerpt

Individual variation in the age of pubertal onset is linked to physical and mental health, yet the factors underlying this variation are poorly understood. Life history theory predicts that individuals at higher risk of mortality due to extrinsic causes such as infectious disease should sexually mature and reproduce earlier, whereas those at lower risk can delay puberty and continue to invest resources in somatic...

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Identifiers

PMID: 34615944
DOI: 10.1038/s41598-021-99334-5
PMCID: PMC8494901

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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