Article
Two component system CpxR/A regulates the prodigiosin biosynthesis by negative control in Serratia marcescens FS14.
Biochemical and biophysical research communications - 19 Nov 2021
Qiu Shenshen, Jia Shanshan, Zhang Fan, Liu Xia, Ran Tingting, Wang Weiwu, Wang Changlin, Xu Dongqing
Abstract excerpt
Prodigiosin is a tripyrrole red secondary metabolite synthesized by many microorganisms, including Serratia marcescens. In this study, we found that the deletion of the gene of sensor kinase CpxA dramatically decreased the prodigiosin production, while the deletion of the gene of the response regulator CpxR or both genes of CpxRA has no effect on prodigiosin production, the kinase function of CpxA is not...
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