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Article

Neurological disorder-associated genetic variants in individuals with psychogenic nonepileptic seizures.

Scientific reports - 16 Sept 2020

Leu Costin, Bautista Jocelyn F, Sudarsanam Monica, Niestroj Lisa-Marie, Stefanski Arthur, Ferguson Lisa, Daly Mark J, Jehi Lara, Najm Imad M, Busch Robyn M, Lal Dennis

Abstract excerpt

Psychogenic nonepileptic seizures (PNES) are diagnosed in approximately 30% of patients referred to tertiary care epilepsy centers. Little is known about the molecular pathology of PNES, much less about possible underlying genetic factors. We generated whole-exome sequencing and whole-genome genotyping data to identify rare, pathogenic (P) or likely pathogenic (LP) variants in 102 individuals with PNES and 448...

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Share to Chromosomes, Human
Share to Epilepsies, Partial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epilepsy, Generalized

Share to Exome Sequencing

Share to Histone-Lysine N-Methyltransferase

Share to Receptors, GABA-A

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Share to Sequence Deletion

Source

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Identifiers

PMID: 32938993
DOI: 10.1038/s41598-020-72101-8
PMCID: PMC7495430

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