Circulating MicroRNAs Highly Correlate to Expression of Cartilage Genes Potentially Reflecting OA Susceptibility-Towards Identification of Applicable Early OA Biomarkers.

doi:10.3390/biom11091356

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Article

Circulating MicroRNAs Highly Correlate to Expression of Cartilage Genes Potentially Reflecting OA Susceptibility-Towards Identification of Applicable Early OA Biomarkers.

Biomolecules - 13 Sept 2021

Ramos Yolande F M, Coutinho de Almeida Rodrigo, Lakenberg Nico, Suchiman Eka, Mei Hailiang, Kloppenburg Margreet, Nelissen Rob G H H, Meulenbelt Ingrid

Abstract excerpt

OBJECTIVE: To identify and validate circulating micro RNAs (miRNAs) that mark gene expression changes in articular cartilage early in osteoarthritis (OA) pathophysiology process. METHODS: Within the ongoing RAAK study, human preserved OA cartilage and plasma (N = 22 paired samples) was collected for RNA sequencing (respectively mRNA and miRNA). Spearman correlation was determined for 114 cartilage genes...

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PMID: 34572569
DOI: 10.3390/biom11091356
PMCID: PMC8468331

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