Two-Step In Vitro Model to Evaluate the Cellular Immune Response to SARS-CoV-2.

doi:10.3390/cells10092206

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Two-Step In Vitro Model to Evaluate the Cellular Immune Response to SARS-CoV-2.

Cells - 26 Aug 2021

Melgaço Juliana G, Azamor Tamiris, Silva Andréa M V, Linhares José Henrique R, Dos Santos Tiago P, Mendes Ygara S, de Lima Sheila M B, Fernandes Camilla Bayma, da Silva Jane, de Souza Alessandro F, Tubarão Luciana N, Brito E Cunha Danielle, Pereira Tamires B S, Menezes Catarina E L, Miranda Milene D, Matos Aline R, Caetano Braulia C, Martins Jéssica S C C, Calvo Thyago L, Rodrigues Natalia F, Sacramento Carolina Q, Siqueira Marilda M, Moraes Milton O, Missailidis Sotiris, Neves Patrícia C C, Ano Bom Ana Paula D

Abstract excerpt

The cellular immune response plays an important role in COVID-19, caused by SARS-CoV-2. This feature makes use of in vitro models' useful tools to evaluate vaccines and biopharmaceutical effects. Here, we developed a two-step model to evaluate the cellular immune response after SARS-CoV-2 infection-induced or spike protein stimulation in peripheral blood mononuclear cells (PBMC) from both unexposed and COVID-19...

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Identifiers

PMID: 34571855
DOI: 10.3390/cells10092206
PMCID: PMC8465121

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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