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Accelerated loss of oogonia and impaired folliculogenesis in females with Turner syndrome start during early fetal development

8 Sept 2021

Abstract excerpt

STUDY QUESTION: How are germ cell numbers and initiation of folliculogenesis affected in fetal Turner syndrome (TS) ovaries? SUMMARY ANSWER: Germ cell development was severely affected already in early second trimester pregnancies, including accelerated oogonia loss and impaired initiation of primordial follicle formation in TS ovaries, while the phenotype in TS mosaic ovaries was less severe. WHAT IS KNOWN...

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PMID: 34568940
DOI: 10.1093/humrep/deab210

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