Effect of CAG repeats on the age at onset of patients with spinocerebellar ataxia type 2 in China.

doi:10.11817/j.issn.1672-7347.2021.210230

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Article

Effect of CAG repeats on the age at onset of patients with spinocerebellar ataxia type 2 in China.

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences - 28 Aug 2021

Li Yu, Liu Zhen, Hou Xiaorong, Chen Zhao, Shen Lu, Xia Kun, Tang Beisha, Jiang Hong, Wang Junling

Abstract excerpt

OBJECTIVES: Spinocerebellar ataxia type 2 (SCA2) is one of the most common autosomal dominant ataxias in the world. Several reports revealed that CAG repeats in some polyQ-containing genes may affect the age at onset (AAO) of patients with SCA2, however, little studies were conducted among Chinese patients with SCA2. Thus, the aim of this study is to evaluate the effect of CAG repeats on the AAO of patients with...

Topics

Age of Onset
Alleles
China
Humans
Nerve Tissue Proteins
Spinocerebellar Ataxias

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Identifiers

PMID: 34565721
DOI: 10.11817/j.issn.1672-7347.2021.210230
PMCID: PMC10929981

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