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Does large NGS panel analysed using exome tumour sequencing improve the management of advanced non-small-cell lung cancers?

Lung cancer (Amsterdam, Netherlands) - 1 Nov 2021

Niogret Julie, Dalens Lorraine, Truntzer Caroline, Chevrier Sandy, Favier Laure, Lagrange Aurélie, Coudert Bruno, Fraisse Cléa, Foucher Pascal, Zouak Ayoub, Westeel Virginie, Goussot Vincent, Dérangère Valentin, Albuisson Juliette, Arnould Laurent, Boidot Romain, Kaderbhai Courèche-Guillaume, Ghiringhelli François

Abstract excerpt

INTRODUCTION: Non-small-cell lung cancer (NSCLC) is one of the most common and deadly cancers. Several molecular drivers of oncogene addiction are now known to be strong predictive biomarkers for target therapies. Advances in large Next Generation Sequencing (LNGS) have improved the ability to detect potentially targetable mutations. However, the integration of LNGS into clinical management in an individualized...

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PMID: 34560426
DOI: 10.1016/j.lungcan.2021.08.013

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