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Reverse transcription recombinase-aided amplification assay for rapid detection of the influenza A(H1N1)pdm09 H275Y mutation that confers oseltamivir resistance.

Molecular and cellular probes - 1 Dec 2021

Li Jun, Yang Zi, Mao Ling-Feng, Chen Ren-Hua, Yu Xin-Fen, Yang Xu-Hui, Zhang Guo-Zhong, Wang Hao-Qiu, Chen Shu-Chang, Zhao Gang

Abstract excerpt

The emergence of the influenza A(H1N1)pdm09 virus with the NA-H275Y mutation, which confers oseltamivir resistance, must be monitored, especially in patients undergoing neuraminidase inhibitor treatment. In this study, we developed a reverse transcription recombinase-aided amplification assay that has high sensitivity (detection limit: 1.0 × 101 copies/μL) and specificity for detecting the oseltamivir-resistant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34560257
DOI: 10.1016/j.mcp.2021.101771

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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