LDLR gene polymorphism (rs688) affects susceptibility to cardiovascular disease in end-stage kidney disease patients.

doi:10.1186/s12882-021-02532-6

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Article

LDLR gene polymorphism (rs688) affects susceptibility to cardiovascular disease in end-stage kidney disease patients.

BMC nephrology - 23 Sept 2021

Buraczynska Monika, Jacob Jerry, Gwiazda-Tyndel Karolina, Ksiazek Andrzej

Abstract excerpt

BACKGROUND: The low-density lipoprotein receptor (LDLR) plays a significant role in maintaining the cellular cholesterol homeostasis. Mutations in the LDLR gene can lead to a significant rise in plasma LDL levels that may result in an increased risk of atherosclerosis and coronary heart disease. The purpose of this study was to assess the potential association of the LDLR rs688 polymorphism with cardiovascular...

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PMID: 34556050
DOI: 10.1186/s12882-021-02532-6
PMCID: PMC8459523

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