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Article

Screening for hypophosphatasia: does biochemistry lead the way?

Journal of pediatric endocrinology & metabolism : JPEM - 23 Feb 2022

Held Corinna Melanie, Guebelin Anic, Krebs Andreas, Sass Jörn Oliver, Wurm Michael, Lausch Ekkehart, van der Werf-Grohmann Natascha, Schwab Karl Otfried

Abstract excerpt

OBJECTIVES: Patients with childhood hypophosphatasia (HPP) often have unspecific symptoms. It was our aim to identify patients with mild forms of HPP by laboratory data screening for decreased alkaline phosphatase (AP) within a pediatric population. METHODS: We conducted a retrospective hospital-based data screening for AP activity below the following limits: Girls: ≤12 years: <125 U/L; >12 years: <50 U/L...

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Source

Identifiers

PMID: 34551461
DOI: 10.1515/jpem-2021-0104

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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