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Article

A Diagnostic Algorithm for Children with Low Alkaline Phosphatase Activities: Lessons Learned from Laboratory Screening for Hypophosphatasia.

The Journal of pediatrics - 1 May 2016

Saraff Vrinda, Narayanan Vidya K, Lawson Alexander J, Shaw Nicholas J, Preece Mary Anne, Högler Wolfgang

Abstract excerpt

OBJECTIVES: To explore the role of laboratory screening for hypophosphatasia and propose a diagnostic pathway for children with low serum alkaline phosphatase (ALP) activities. STUDY DESIGN: A retrospective hospital-based study over an 8-year period was conducted to identify children younger than 16 years of age with low ALP activity (<100 U/L). Study-positive patients were contacted for repeat sampling, and...

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Source

Identifiers

PMID: 26896157
DOI: 10.1016/j.jpeds.2016.01.045

Genes

ALPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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