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Detection of SARS-CoV-2 with Solid-State CRISPR-Cas12a-Assisted Nanopores

20 Sept 2021

Abstract excerpt

The outbreak of the SARS-CoV-2 caused the disease COVID-19 to spread globally. Specific and sensitive detection of SARS-CoV-2 facilitates early intervention and prevents the disease from spreading. Here, we present a solid-state CRISPR-Cas12a-assisted nanopore (SCAN) sensing strategy for the specific detection of SARS-CoV-2. We introduced a nanopore-sized counting method to measure the cleavage ratio of...

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PMID: 34542296
DOI: 10.1021/acs.nanolett.1c02974

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