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Epigenetics effect on pathogenesis of thyroid-associated ophthalmopathy

23 Aug 2021

Abstract excerpt

Thyroid-associated ophthalmopathy (TAO) is an autoimmune disease. Recent studies have found the aberrant epigenetics in TAO, including DNA methylation, non-coding RNAs, and histone modification. Many genes have an aberrant level of methylation in TAO. For example, higher levels are found in CD14, MBP, ANGLE1, LYAR and lower levels in DRD4 and BOLL. Non-coding RNAs are involved in the immune response (miR-146a,...

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PMID: 34540623
DOI: 10.18240/ijo.2021.09.22

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