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TRIM25 inhibits infectious bursal disease virus replication by targeting VP3 for ubiquitination and degradation

13 Sept 2021

Abstract excerpt

Infectious bursal disease virus (IBDV), a double-stranded RNA virus, causes immunosuppression and high mortality in 3-6-week-old chickens. Innate immune defense is a physical barrier to restrict viral replication. After viral infection, the host shows crucial defense responses, such as stimulation of antiviral effectors to restrict viral replication. Here, we conducted RNA-seq in avian cells infected by IBDV and...

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PMID: 34516573
DOI: 10.1371/journal.ppat.1009900

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