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Survival of bladder or renal cancer in patients with CHEK2 mutations.

PloS one - 1 Jan 2021

Złowocka-Perłowska Elżbieta, Dębniak Tadeusz, Słojewski Marcin, van de Wetering Thierry, Tołoczko-Grabarek Aleksandra, Cybulski Cezary, Scott Rodney J, Lubiński Jan

Abstract excerpt

PURPOSE: The purpose of this study was to compare the clinical characteristics and the survival of CHEK2 mutation positive and CHEK2 mutation negative patients diagnosed with bladder or kidney cancer. MATERIALS AND METHODS: 1016 patients with bladder and 402 cases with kidney cancer and 8302 controls were genotyped for four CHEK2 variants: 1100delC, del5395, IVS2+1G>A and I157T. Predictors of survival were...

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Identifiers

PMID: 34499690
DOI: 10.1371/journal.pone.0257132
PMCID: PMC8428549

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