Article
Ultrafast homomorphic encryption models enable secure outsourcing of genotype imputation.
Cell systems - 17 Nov 2021
Kim Miran, Harmanci Arif Ozgun, Bossuat Jean-Philippe, Carpov Sergiu, Cheon Jung Hee, Chillotti Ilaria, Cho Wonhee, Froelicher David, Gama Nicolas, Georgieva Mariya, Hong Seungwan, Hubaux Jean-Pierre, Kim Duhyeong, Lauter Kristin, Ma Yiping, Ohno-Machado Lucila, Sofia Heidi, Son Yongha, Song Yongsoo, Troncoso-Pastoriza Juan, Jiang Xiaoqian
Abstract excerpt
Genotype imputation is a fundamental step in genomic data analysis, where missing variant genotypes are predicted using the existing genotypes of nearby "tag" variants. Although researchers can outsource genotype imputation, privacy concerns may prohibit genetic data sharing with an untrusted imputation service. Here, we developed secure genotype imputation using efficient homomorphic encryption (HE) techniques....
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