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Article

Privacy-preserving genotype imputation with fully homomorphic encryption.

Cell systems - 16 Feb 2022

Gürsoy Gamze, Chielle Eduardo, Brannon Charlotte M, Maniatakos Michail, Gerstein Mark

Abstract excerpt

Genotype imputation is the inference of unknown genotypes using known population structure observed in large genomic datasets; it can further our understanding of phenotype-genotype relationships and is useful for QTL mapping and GWASs. However, the compute-intensive nature of genotype imputation can overwhelm local servers for computation and storage. Hence, many researchers are moving toward using cloud...

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PMID: 34758288
DOI: 10.1016/j.cels.2021.10.003
PMCID: PMC8857019

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