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Article

Privacy-preserving genotype imputation in a trusted execution environment.

Cell systems - 20 Oct 2021

Dokmai Natnatee, Kockan Can, Zhu Kaiyuan, Wang XiaoFeng, Sahinalp S Cenk, Cho Hyunghoon

Abstract excerpt

Genotype imputation is an essential tool in genomics research, whereby missing genotypes are inferred using reference genomes to enhance downstream analyses. Recently, public imputation servers have allowed researchers to leverage large-scale genomic data resources for imputation. However, privacy concerns about uploading one's genetic data to a server limit the utility of these services. We introduce a secure...

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PMID: 34450045
DOI: 10.1016/j.cels.2021.08.001
PMCID: PMC8542641

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