Article
Campylobacter jejuni genotypes are associated with post-infection irritable bowel syndrome in humans.
Communications biology - 30 Aug 2021
Peters Stephanie, Pascoe Ben, Wu Zuowei, Bayliss Sion C, Zeng Ximin, Edwinson Adam, Veerabadhran-Gurunathan Sakteesh, Jawahir Selina, Calland Jessica K, Mourkas Evangelos, Patel Robin, Wiens Terra, Decuir Marijke, Boxrud David, Smith Kirk, Parker Craig T, Farrugia Gianrico, Zhang Qijing, Sheppard Samuel K, Grover Madhusudan
Abstract excerpt
Campylobacter enterocolitis may lead to post-infection irritable bowel syndrome (PI-IBS) and while some C. jejuni strains are more likely than others to cause human disease, genomic and virulence characteristics promoting PI-IBS development remain uncharacterized. We combined pangenome-wide association studies and phenotypic assays to compare C. jejuni isolates from patients who developed PI-IBS with those who...
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