Clinical Relevance of VEGFA (rs3025039) +936 C>T Polymorphism in Primary Myelofibrosis: Susceptibility, Clinical Co-Variates, and Outcomes.

doi:10.3390/genes12081271

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Article

Clinical Relevance of VEGFA (rs3025039) +936 C>T Polymorphism in Primary Myelofibrosis: Susceptibility, Clinical Co-Variates, and Outcomes.

Genes - 20 Aug 2021

Villani Laura, Carolei Adriana, Rosti Vittorio, Massa Margherita, Campanelli Rita, Catarsi Paolo, Abbà Carlotta, Gale Robert Peter, Barosi Giovanni

Abstract excerpt

We evaluated the association of VEGFA rs3025039 polymorphism with clinical co-variates and outcomes in 849 subjects with primary myelofibrosis (PMF) and 250 healthy controls. Minor T-allele frequency was higher in subjects with JAK2V617F compared with those without JAK2V617F (18% vs. 13%; p = 0.014). In subjects with JAK2V617F, the TT genotype was associated at diagnosis with lower platelet concentrations (p =...

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PMID: 34440447
DOI: 10.3390/genes12081271
PMCID: PMC8393853

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