Article
Gene replacement therapy for retinal CNG channelopathies.
Molecular genetics and genomics : MGG - 1 Oct 2013
Schön Christian, Biel Martin, Michalakis Stylianos
Abstract excerpt
Visual phototransduction relies on the function of cyclic nucleotide-gated channels in the rod and cone photoreceptor outer segment plasma membranes. The role of these ion channels is to translate light-triggered changes in the second messenger cyclic guanosine 3'-5'-monophosphate levels into an electrical signal that is further processed within the retinal network and then sent to higher visual centers. Rod and...
Topics
- Animals
- Channelopathies
- Color Vision Defects
- Cyclic Nucleotide-Gated Cation Channels
- Dependovirus
- Genetic Therapy
- Genetic Vectors
- Humans
- Models, Animal
- Models, Molecular
- Mutation