A powerful adaptive microbiome-based association test for microbial association signals with diverse sparsity levels.

Abstract excerpt

The dysbiosis of microbiome may have negative effects on a host phenotype. The microbes related to the host phenotype are regarded as microbial association signals. Recently, statistical methods based on microbiome-phenotype association tests have been extensively developed to detect these association signals. However, the currently available methods do not perform well to detect microbial association signals when...

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