Article
Membrane Bound Peroxiredoxin-1 Serves as a Biomarker for In Vivo Detection of Sessile Serrated Adenomas.
Antioxidants & redox signaling - 1 Jan 2022
Jaiswal Sangeeta, Joshi Bishnu, Chen Jing, Wang Fa, Dame Michael K, Spence Jason R, Newsome Gina M, Katz Erica L, Shah Yatrik M, Ramakrishnan Sadeesh K, Li Gaoming, Lee Miki, Appelman Henry D, Kuick Rork, Wang Thomas D
Abstract excerpt
Aim: Sessile serrated adenomas (SSAs) are premalignant lesions driven by the BRAFV600E mutation to give rise to colorectal cancers (CRCs). They are often missed during white light colonoscopy because of their subtle appearance. Previously, a fluorescently labeled 7mer peptide KCCFPAQ was shown to detect SSAs in vivo. We aim to identify the target of this peptide. Results: Peroxiredoxin-1 (Prdx1) was identified as...
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