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Evidence of new intragenic HBB haplotypes model for the prediction of beta-thalassemia in the Malaysian population.

Scientific reports - 18 Aug 2021

Aziz Nur-Aisyah, Taib Wan-Rohani Wan, Kharolazaman Nur-Khairunnisa, Ismail Imilia, Al-Jamal Hamid Ali Nagi, Jamil Nadiah Wan-Arfah Wan Abdul, Esa Ezalia, Ibrahim Hishamshah

Abstract excerpt

This study sought to determine the potential role of HBB haplotypes to predict beta-thalassemia in the Malaysian population. A total of 543 archived samples were selected for this study. Five tagging SNPs in the beta-globin gene (HBB; NG_000007.3) were analyzed for SNP-based and haplotype association using SHEsis online software. Single-SNP-based association analysis showed three SNPs have a statistically...

Topics

Female
Haplotypes
Humans
Malaysia
Male
Models, Genetic
Polymorphism, Single Nucleotide
beta-Globins
beta-Thalassemia

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34408192
DOI: 10.1038/s41598-021-96018-y
PMCID: PMC8373976

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