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Article

AtHDA6 functions as an H3K18ac eraser to maintain pericentromeric CHG methylation in Arabidopsis thaliana.

Nucleic acids research - 27 Sept 2021

Wang Qianwen, Bao Xiucong, Chen Shengjie, Zhong Huan, Liu Yaqin, Zhang Li, Xia Yiji, Kragler Friedrich, Luo Ming, Li Xiang David, Lam Hon-Ming, Zhang Shoudong

Abstract excerpt

Pericentromeric DNA, consisting of high-copy-number tandem repeats and transposable elements, is normally silenced through DNA methylation and histone modifications to maintain chromosomal integrity and stability. Although histone deacetylase 6 (HDA6) has been known to participate in pericentromeric silencing, the mechanism is still yet unclear. Here, using whole genome bisulfite sequencing (WGBS) and chromatin...

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PMID: 34403482
DOI: 10.1093/nar/gkab706
PMCID: PMC8464031

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