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Whole-Exome Sequencing Identifies a Recurrent Small In-Frame Deletion in MYO15A Causing Autosomal Recessive Nonsyndromic Hearing Loss in 3 Iranian Pedigrees.

Laboratory medicine - 7 Mar 2022

Nasrniya Samane, Miar Paniz, Narrei Sina, Sepehrnejad Mahsa, Nilforoush Mohammad Hussein, Abtahi Hamidreza, Tabatabaiefar Mohammad Amin

Abstract excerpt

BACKGROUND: Hearing loss (HL) is the most prevalent and genetically heterogeneous sensory disabilities in humans throughout the world. METHODS: In this study, we used whole-exome sequencing (WES) to determine the variant causing autosomal recessive nonsyndromic hearing loss (ARNSHL) segregating in 3 separate Iranian consanguineous families (with 3 different ethnicities: Azeri, Persian, and Lur), followed by...

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PMID: 34388253
DOI: 10.1093/labmed/lmab047

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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Whole-Exome Sequencing Identifies a Recurrent Small In-Frame Deletion in MYO15A Causing Autosomal Recessive Nonsyndromic Hearing Loss in 3 Iranian Pedigrees.PMID 34388253Read ↗

Novel MYO15A variants are associated with hearing loss in the two Iranian pedigrees.Semantic proximity Read ↗

Novel MYO15A Variants are Associated with Hearing Loss in the Two Iranian PedigreesSemantic proximity Read ↗

Whole exome sequencing identifies novel compound heterozygous pathogenic variants in the MYO15A gene leading to autosomal recessive non-syndromic hearing loss.Semantic proximity Read ↗

Novel compound heterozygous mutations in the MYO15A gene in autosomal recessive hearing loss identified by whole-exome sequencing.Semantic proximity Read ↗

Whole-exome sequencing of Iranian families identifies novel variants underlying congenital hearing lossSemantic proximity Read ↗

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