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Availability of HLA-allele-matched unrelated donors and registry size: Estimation from haplotype frequency in the Italian population.

Human immunology - 1 Oct 2021

Sacchi N, Ciceri F, Bonifazi F, Algeri M, Gallina A, Pollichieni S, Raggio E, Hadj-Amar B, Lombardini L, Pupella S, Liumbruno G, Cardillo M

Abstract excerpt

In Italy, an HLA-matched unrelated donor is currently the primary donor when a HLA matched sibling is not found for allogeneic haematopoietic stem cell transplantation (HSCT). Better outcomes for transplantation require optimal matching between donor and recipient at least at the HLA-A, -B, -C, and -DRB1 loci; therefore, the availability of HLA-matched unrelated donors is important. The enormous HLA polymorphism...

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PMID: 34353675
DOI: 10.1016/j.humimm.2021.07.012

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