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Article

RYR1-Related Rhabdomyolysis: A Spectrum of Hypermetabolic States Due to Ryanodine Receptor Dysfunction.

Current pharmaceutical design - 1 Jan 2022

Kruijt Nick, den Bersselaar Luuk Van, Snoeck Marc, Kramers Kees, Riazi Sheila, Bongers Coen, Treves Susan, Jungbluth Heinz, Voermans Nicol

Abstract excerpt

Variants in the ryanodine receptor-1 gene (RYR1) have been associated with a wide range of neuromuscular conditions, including various congenital myopathies and malignant hyperthermia (MH). More recently, a number of RYR1 variants, mostly MH-associated, have been demonstrated to contribute to rhabdomyolysis events not directly related to anesthesia in otherwise healthy individuals. This review focuses on...

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Identifiers

PMID: 34348614
DOI: 10.2174/1381612827666210804095300

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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