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Article

Clinicopathological significance of primitive phenotypes in early gastric cancer with differentiated histology.

Diagnostic pathology - 31 Jul 2021

Zhou Zhi-Yi, Sun Jie, Guo Qing, Zhao Hai-Bin, Zhou Zhi-Hua

Abstract excerpt

BACKGROUND: Certain gastric cancers exhibit some primitive phenotypes, which may indicate a high malignancy. In histologically differentiated early gastric cancer (EGC), the presence and the clinicopathological significance of the primitive phenotype remain unclear. METHODS: Using immunohistochemical staining we detected the expression of three primitive phenotypic markers SALL4, Glypican-3(GPC3), and AFP in...

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Identifiers

PMID: 34332604
DOI: 10.1186/s13000-021-01128-w
PMCID: PMC8325828

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