Article
Sequencing of a central nervous system tumor demonstrates cancer transmission in an organ transplant.
Life science alliance - 1 Sept 2021
Gingras Marie-Claude, Sabo Aniko, Cardenas Maria, Rana Abbas, Dhingra Sadhna, Meng Qingchang, Hu Jianhong, Muzny Donna M, Doddapaneni Harshavardhan, Perez Lesette, Korchina Viktoriya, Nessner Caitlin, Liu Xiuping, Chao Hsu, Goss John, Gibbs Richard A
Abstract excerpt
Four organ transplant recipients from an organ donor diagnosed with anaplastic pleomorphic xanthoastrocytoma developed fatal malignancies for which the origin could not be confirmed by standard methods. We identified the somatic mutational profiles of the neoplasms using next-generation sequencing technologies and tracked the relationship between the different samples. The data were consistent with the presence...
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