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Article

Archival bone marrow smears are useful in targeted next-generation sequencing for diagnosing myeloid neoplasms.

PloS one - 1 Jan 2021

Sadato Daichi, Hirama Chizuko, Kaiho-Soma Ai, Yamaguchi Ayaka, Kogure Hiroko, Takakuwa Sonomi, Ogawa Mina, Doki Noriko, Ohashi Kazuteru, Harada Hironori, Oboki Keisuke, Harada Yuka

Abstract excerpt

Gene abnormalities, including mutations and fusions, are important determinants in the molecular diagnosis of myeloid neoplasms. The use of bone marrow (BM) smears as a source of DNA and RNA for next-generation sequencing (NGS) enables molecular diagnosis to be done with small amounts of bone marrow and is especially useful for patients without stocked cells, DNA or RNA. The present study aimed to analyze the...

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PMID: 34297770
DOI: 10.1371/journal.pone.0255257
PMCID: PMC8301613

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