Article
[Clinical and molecular genetic features of 3 family cases of the central precocious puberty, due to MKRN3 gene defects].
Problemy endokrinologii - 11 May 2021
Zubkova N A, Kolodkina A A, Makretskaya N A, Okorokov P L, Pogoda T V, Vasiliev E V, Petrov V M, Tiulpakov A N
Abstract excerpt
Gonadotropin-dependent precocious puberty (central) is a condition resulting from the early (up to 8 years in girls and 9 years in boys) reactivation of the hypothalamic-pituitary-gonadal axis. An increase in the secretion of sex steroids by the gonads in this form is a consequence of the stimulation of the sex glands by gonadotropic hormones of the pituitary gland. In the absence of central nervous system...
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