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Article

Quantifying the contribution of Neanderthal introgression to the heritability of complex traits.

Nature communications - 22 Jul 2021

McArthur Evonne, Rinker David C, Capra John A

Abstract excerpt

Eurasians have ~2% Neanderthal ancestry, but we lack a comprehensive understanding of the genome-wide influence of Neanderthal introgression on modern human diseases and traits. Here, we quantify the contribution of introgressed alleles to the heritability of more than 400 diverse traits. We show that genomic regions in which detectable Neanderthal ancestry remains are depleted of heritability for all traits...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34294692
DOI: 10.1038/s41467-021-24582-y
PMCID: PMC8298587

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