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Article

The phenotypic legacy of admixture between modern humans and Neandertals.

Science (New York, N.Y.) - 12 Feb 2016

Simonti Corinne N, Vernot Benjamin, Bastarache Lisa, Bottinger Erwin, Carrell David S, Chisholm Rex L, Crosslin David R, Hebbring Scott J, Jarvik Gail P, Kullo Iftikhar J, Li Rongling, Pathak Jyotishman, Ritchie Marylyn D, Roden Dan M, Verma Shefali S, Tromp Gerard, Prato Jeffrey D, Bush William S, Akey Joshua M, Denny Joshua C, Capra John A

Abstract excerpt

Many modern human genomes retain DNA inherited from interbreeding with archaic hominins, such as Neandertals, yet the influence of this admixture on human traits is largely unknown. We analyzed the contribution of common Neandertal variants to over 1000 electronic health record (EHR)-derived phenotypes in ~28,000 adults of European ancestry. We discovered and replicated associations of Neandertal alleles with...

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Identifiers

PMID: 26912863
DOI: 10.1126/science.aad2149
PMCID: PMC4849557

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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