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Oxidative stress in obesity-associated hepatocellular carcinoma: sources, signaling and therapeutic challenges

21 Jul 2021

Abstract excerpt

Obesity affects more than 650 million individuals worldwide and is a well-established risk factor for the development of hepatocellular carcinoma (HCC). Oxidative stress can be considered as a bona fide tumor promoter, contributing to the initiation and progression of liver cancer. Indeed, one of the key events involved in HCC progression is excessive levels of reactive oxygen species (ROS) resulting from the...

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PMID: 34290399
DOI: 10.1038/s41388-021-01950-y

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