Sarcopenia associates with SNAP-25 SNPs and a miRNAs profile which is modulated by structured rehabilitation treatment.

doi:10.1186/s12967-021-02989-x

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Article

Sarcopenia associates with SNAP-25 SNPs and a miRNAs profile which is modulated by structured rehabilitation treatment.

Journal of translational medicine - 21 Jul 2021

Agostini Simone, Mancuso Roberta, Costa Andrea Saul, Guerini Franca Rosa, Trecate Fabio, Miglioli Rossella, Menna Elisabetta, Arosio Beatrice, Clerici Mario

Abstract excerpt

BACKGROUND: Sarcopenia is a loss of muscle mass and strength causing disability, morbidity, and mortality in older adults, which is characterized by alterations of the neuromuscular junctions (NMJs). SNAP-25 is essential for the maintenance of NMJ integrity, and the expression of this protein was shown to be modulated by the SNAP-25 rs363050 polymorphism and by a number of miRNAs. METHODS: We analysed these...

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PMID: 34289870
DOI: 10.1186/s12967-021-02989-x
PMCID: PMC8296538

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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