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Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition?

18 Jul 2021

Abstract excerpt

The precise mechanistic action of acetaminophen (ACT; paracetamol) remains debated. ACT's analgesic and antipyretic actions are attributed to cyclooxygenase (COX) inhibition preventing prostaglandin (PG) synthesis. Two COX isoforms (COX1/2) share 60% sequence structure, yet their functions vary. COX variants have been sequenced among various mammalian species including humans. A COX1 splice variant (often termed...

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PMID: 34278737
DOI: 10.1002/prp2.835

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