Article
Global REACH 2018: the adaptive phenotype to life with chronic mountain sickness and polycythaemia.
The Journal of physiology - 1 Sept 2021
Hansen Alexander B, Moralez Gilbert, Amin Sachin B, Simspon Lydia L, Hofstaetter Florian, Anholm James D, Gasho Christopher, Stembridge Mike, Dawkins Tony G, Tymko Michael M, Ainslie Philip N, Villafuerte Francisco, Romero Steven A, Hearon Christopher M, Lawley Justin S
Abstract excerpt
KEY POINTS: Humans suffering from polycythaemia undergo multiple circulatory adaptations including changes in blood rheology and structural and functional vascular adaptations to maintain normal blood pressure and vascular shear stresses, despite high blood viscosity. During exercise, several circulatory adaptations are observed, especially involving adrenergic and non-adrenergic mechanisms within non-active and...
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