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Article

Mechanism of BIP-4 mediated inhibition of InsP3Kinase-A.

Bioscience reports - 30 Jul 2021

Paraschiakos Themistoklis, Flat Wilhelm, Chen Ya, Kirchmair Johannes, Windhorst Sabine

Abstract excerpt

Overexpression of the neuronal InsP3kinase-A increases malignancy of different tumor types. Since InsP3kinase-A highly selectively binds Ins(1,4,5)P3, small molecules competing with Ins(1,4,5)P3 provide a promising approach for the therapeutic targeting of InsP3kinase-A. Based on this consideration, we analyzed the binding mechanism of BIP-4 (2-[3,5-dimethyl-1-(4-nitrophenyl)-1H-pyrazol-4-yl]-5,...

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Identifiers

PMID: 34232294
DOI: 10.1042/BSR20211259
PMCID: PMC8292763

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