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Article

Insilico study on the effect of SARS-CoV-2 RBD hotspot mutants' interaction with ACE2 to understand the binding affinity and stability.

Virology - 1 Sept 2021

Verma Jyoti, Subbarao Naidu

Abstract excerpt

The fall of 2020 brought several new variants of SARS-CoV-2 circulating across the globe, and the steadily increasing COVID-19 cases are responsible for the emergence of these variants. All the SARS-CoV-2 variants reported to date have multiple mutations in the spike (S) protein, specifically in the receptor-binding domain (RBD). Here, we employed an integrated computational approach involving structure and...

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Identifiers

PMID: 34217923
DOI: 10.1016/j.virol.2021.06.009
PMCID: PMC8237243

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