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Article

Association of Sleep Traits and Heel Bone Mineral Density: Observational and Mendelian Randomization Studies.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Nov 2021

Chen Jie, Zhang Jihui, So Hon Cheong, Ai Sizhi, Wang Ningjian, Tan Xiao, Wing Yun Kwok

Abstract excerpt

Observational studies have suggested that sleep and circadian disturbances are potentially modifiable risk factors for low bone mineral density (BMD), but the causal relationship is unclear. This study aimed to (i) replicate the findings by examining observational association of sleep traits with low estimated BMD); (ii) examine whether these associations were causal by using Mendelian randomization (MR)...

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PMID: 34184784
DOI: 10.1002/jbmr.4406

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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