Genome-Wide Association Study Identifies Risk Loci for Cluster Headache.

doi:10.1002/ana.26150

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Article

Genome-Wide Association Study Identifies Risk Loci for Cluster Headache.

Annals of neurology - 1 Aug 2021

O'Connor Emer, Fourier Carmen, Ran Caroline, Sivakumar Prasanth, Liesecke Franziska, Southgate Laura, Harder Aster V E, Vijfhuizen Lisanne S, Yip Janice, Giffin Nicola, Silver Nicholas, Ahmed Fayyaz, Hostettler Isabel C, Davies Brendan, Cader M Zameel, Simpson Benjamin S, Sullivan Roisin, Efthymiou Stephanie, Adebimpe Joycee, Quinn Olivia, Campbell Ciaran, Cavalleri Gianpiero L, Vikelis Michail, Kelderman Tim, Paemeleire Koen, Kilbride Emer, Grangeon Lou, Lagrata Susie, Danno Daisuke, Trembath Richard, Wood Nicholas W, Kockum Ingrid, Winsvold Bendik S, Steinberg Anna, Sjöstrand Christina, Waldenlind Elisabet, Vandrovcova Jana, Houlden Henry, Matharu Manjit, Belin Andrea Carmine

Abstract excerpt

OBJECTIVE: This study was undertaken to identify susceptibility loci for cluster headache and obtain insights into relevant disease pathways. METHODS: We carried out a genome-wide association study, where 852 UK and 591 Swedish cluster headache cases were compared with 5,614 and 1,134 controls, respectively. Following quality control and imputation, single variant association testing was conducted using a...

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PMID: 34184781
DOI: 10.1002/ana.26150
PMCID: PMC7619354

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