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Article

Response to lorlatinib on a patient with ALK-rearranged non-small cell lung cancer harboring 1151Tins mutation with uterine metastasis.

Thoracic cancer - 1 Aug 2021

Kobayashi Takashi, Kanda Shintaro, Fukushima Toshirou, Noguchi Takuro, Sekiguchi Nodoka, Koizumi Tomonobu

Abstract excerpt

We describe a case of an anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer with development of uterine metastasis after crizotinib and alectinib treatment. Gene analysis from the tissue of uterine metastasis revealed the presence of 1151Tins, which was considered to be a crizotinib and alectinib resistance mutation. Subsequent therapy with the third-generation ALK inhibitor lorlatinib, but...

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Identifiers

PMID: 34184417
DOI: 10.1111/1759-7714.14056
PMCID: PMC8365006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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