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Detection of gut microbiota and pathogen produced N-acyl homoserine in host circulation and tissues

28 Jun 2021

Abstract excerpt

Recent studies suggest that quorum-sensing molecules may play a role in gut microbiota-host crosstalk. However, whether microbiota produces quorum-sensing molecules and whether those molecules can trans-kingdom transport to the host are still unknown. Here, we develop a UPLC-MS/MS-based assay to screen the 27 N-acyl homoserine lactones (AHLs) in the gut microbiota and host. Various AHL molecules are exclusively...

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PMID: 34183673
DOI: 10.1038/s41522-021-00224-5

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