Article
Short and long sleeping mutants reveal links between sleep and macroautophagy.
eLife - 4 Jun 2021
Bedont Joseph L, Toda Hirofumi, Shi Mi, Park Christine H, Quake Christine, Stein Carly, Kolesnik Anna, Sehgal Amita
Abstract excerpt
Sleep is a conserved and essential behavior, but its mechanistic and functional underpinnings remain poorly defined. Through unbiased genetic screening in Drosophila, we discovered a novel short-sleep mutant we named argus. Positional cloning and subsequent complementation, CRISPR/Cas9 knock-out, and RNAi studies identified Argus as a transmembrane protein that acts in adult peptidergic neurons to regulate sleep....
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