Article
Raised sputum extracellular DNA confers lung function impairment and poor symptom control in an exacerbation-susceptible phenotype of neutrophilic asthma.
Respiratory research - 3 Jun 2021
Abdo Mustafa, Uddin Mohib, Goldmann Torsten, Marwitz Sebastian, Bahmer Thomas, Holz Olaf, Kirsten Anne-Marie, Trinkmann Frederik, von Mutius Erika, Kopp Matthias, Hansen Gesine, Rabe Klaus F, Watz Henrik, Pedersen Frauke
Abstract excerpt
BACKGROUND: Extracellular DNA (e-DNA) and neutrophil extracellular traps (NETs) are linked to asthmatics airway inflammation. However, data demonstrating the characterization of airway inflammation associated with excessive e-DNA production and its impact on asthma outcomes are limited. OBJECTIVE: To characterize the airway inflammation associated with excessive e-DNA production and its association with asthma...
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