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Article

Recombinant γY278H Fibrinogen Showed Normal Secretion from CHO Cells, but a Corresponding Heterozygous Patient Showed Hypofibrinogenemia.

International journal of molecular sciences - 14 May 2021

Kamijo Tomu, Kaido Takahiro, Yoda Masahiro, Arai Shinpei, Yamauchi Kazuyoshi, Okumura Nobuo

Abstract excerpt

We identified a novel heterozygous hypofibrinogenemia, γY278H (Hiroshima). To demonstrate the cause of reduced plasma fibrinogen levels (functional level: 1.12 g/L and antigenic level: 1.16 g/L), we established γY278H fibrinogen-producing Chinese hamster ovary (CHO) cells. An enzyme-linked immunosorbent assay demonstrated that synthesis of γY278H fibrinogen inside CHO cells and secretion into the culture media...

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Identifiers

PMID: 34069309
DOI: 10.3390/ijms22105218
PMCID: PMC8156302

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