Article
Expression of four mutant fibrinogen gammaC domains in Pichia pastoris confirms them as causes of hypofibrinogenaemia.
Protein expression and purification - 1 Oct 2010
Sheen Campbell R, Dear Amy, Brennan Stephen O
Abstract excerpt
Mutations in the fibrinogen gene cluster can cause low plasma fibrinogen concentrations, known as hypofibrinogenaemia. It is important to verify whether a detected sequence variant in this cluster is deleterious or benign and this can be accomplished using protein expression systems. In this stud...
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